Tuesday, February 26, 2008

Maybe you could start off with a definition of histology!!

'Histology' is a funny title for the study of tissues. It comes originally from the Greek noun meaning web and reflects the notion that tissues were composed of a meshwork (a bed or stroma), later thought to be filled by cells (the parenchyma). Originally studied through the chemical analysis of bits and pieces pealed and dissected from cadavers, early histologists destroyed the tissues under scrutiny. As history (different root) unfolded, 'microscopic anatomy' replaced chemistry and would have provided a better title, but early microscopes posed optical problems that clouded issues. Improvements in microscopes and laying causal responsibility for disease at the door or tissues finally gave histology its modern focus. Today, tissues are generally defined by stereotypical characteristics of putatively similar cells present in specific regions or parts of the body, in patterns, or even widely dispersed cells related through development, function, and structure (morphology). Histology has had a renaissance on the heals of monoclonal antibody production, confocal microscopy, fluorescent dyes, in situ hybridization, and in the wake of stem-cell research and regenerative medicine.

Histology Manifesto

Toward a new histology

Amazingly, histology has remained the same as the world has changed. Histologists are in thrall to Virchow but he is only histology's patron saint; he is not its deity. Let us break the bonds of epithelia, connective tissue, muscle, and nerve that bind histologists to an arcane nomenclature! Certainly, germ, blood, and lymphatic cells are entitled to recognition as tissues. Above all, different mechanisms of development should be incorporated into a new histological nomenclature, and, where possible, the evolution of tissues should be acknowledged among their identifying features. Genomics and informatics will provide data, but histologists must provide the impetus!
Please join me in creating a rational new histology where tissues are named, discussed, understood, and taught in ways that reflect what is known and not merely what was known.