Maybe you could start off with a definition of histology!!
'Histology' is a funny title for the study of tissues. It comes originally from the Greek noun meaning web and reflects the notion that tissues were composed of a meshwork (a bed or stroma), later thought to be filled by cells (the parenchyma). Originally studied through the chemical analysis of bits and pieces pealed and dissected from cadavers, early histologists destroyed the tissues under scrutiny. As history (different root) unfolded, 'microscopic anatomy' replaced chemistry and would have provided a better title, but early microscopes posed optical problems that clouded issues. Improvements in microscopes and laying causal responsibility for disease at the door or tissues finally gave histology its modern focus. Today, tissues are generally defined by stereotypical characteristics of putatively similar cells present in specific regions or parts of the body, in patterns, or even widely dispersed cells related through development, function, and structure (morphology). Histology has had a renaissance on the heals of monoclonal antibody production, confocal microscopy, fluorescent dyes, in situ hybridization, and in the wake of stem-cell research and regenerative medicine.
Tuesday, February 26, 2008
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